Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 16/20 | 0.54 |
| ▸ | MAP2K2 | P36507 | 10/20 | 0.54 |
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.40 |
| ▸ | PRKCB | P05771 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | STK3 | Q13188 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.40 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.39 |
| ▸ | IARS2 | Q9NSE4 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1488064 | 1.00 | MAP2K1 (0.54) | MAP2K1MAP2K2IDO1AURKATNFRSF1A | |
| SCHEMBL3527300 | 0.80 | MAP2K1 (0.60) | MAP2K1MAP2K2IDO1DHODH | |
| SCHEMBL5623007 | 0.79 | MAP2K1 (0.79) | MAP2K1MAP2K2IDO1 | |
| SCHEMBL12257051 | 0.78 | MAP2K1 (0.62) | MAP2K1MAP2K2 | |
| SCHEMBL1488519 | 0.77 | MAP2K1 (0.64) | MAP2K1MAP2K2 | |
| SCHEMBL23851097 | 0.75 | MAP2K1 (0.62) | MAP2K1MAP2K2IDO1DHODH | |
| SCHEMBL23851383 | 0.75 | MAP2K1 (0.59) | MAP2K1MAP2K2IDO1AURKATNFRSF1A | |
| SCHEMBL31135614 | 0.75 | MAP2K1 (0.59) | MAP2K1MAP2K2IDO1AURKATNFRSF1A | |
| SCHEMBL31135615 | 0.75 | MAP2K1 (0.62) | MAP2K1MAP2K2IDO1DHODH | |
| SCHEMBL6531054 | 0.74 | MAP2K1 (0.91) | MAP2K1MAP2K2IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109053523-B | Azetidines as MEK inhibitors for the treatment of proliferative diseases | 埃克塞利希斯股份有限公司 | 2022-03-25 | — | — | CN | disclosed |