Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 16/20 | 0.66 |
| ▸ | MAP2K2 | P36507 | 11/20 | 0.66 |
| ▸ | IDO1 | P14902 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 2/20 | 0.44 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.44 |
| ▸ | PRKCB | P05771 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | STK3 | Q13188 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.44 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.43 |
| ▸ | IARS2 | Q9NSE4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1488224 | 1.00 | MAP2K1 (0.66) | MAP2K1MAP2K2IDO1KDM4EAURKA | |
| SCHEMBL2027158 | 0.87 | MAP2K1 (0.63) | MAP2K1MAP2K2IDO1KDM4EAURKA | |
| SCHEMBL2021723 | 0.87 | MAP2K1 (0.63) | MAP2K1MAP2K2IDO1KDM4EAURKA | |
| SCHEMBL188505 | 0.80 | MAP2K1 (1.00) | MAP2K1MAP2K2IDO1 | |
| SCHEMBL30505247 | 0.80 | MAP2K1 (1.00) | MAP2K1MAP2K2IDO1 | |
| SCHEMBL1488391 | 0.80 | MAP2K1 (0.71) | MAP2K1MAP2K2IDO1KDM4EAURKA | |
| SCHEMBL29413559 | 0.80 | MAP2K1 (1.00) | MAP2K1MAP2K2IDO1 | |
| Hydrochloric Acid SCHEMBL30080174 | 0.78 | MAP2K1 (0.97) | MAP2K1MAP2K2IDO1 | |
| SCHEMBL27224629 | 0.78 | MAP2K1 (0.68) | MAP2K1MAP2K2IDO1AURKATNFRSF1A | |
| SCHEMBL29682048 | 0.77 | MAP2K1 (0.64) | MAP2K1MAP2K2IDO1PRKCZIARS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109053523-B | Azetidines as MEK inhibitors for the treatment of proliferative diseases | 埃克塞利希斯股份有限公司 | 2022-03-25 | — | — | CN | disclosed |