SCHEMBL29413623

SCHEMBL29413623

Cn1nc(C(=O)O)c(Nc2ccc(I)cc2F)cc1=O

nearest known ligand 0.62

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MAP2K1 Q02750 20/20 0.62
MAP2K2 P36507 13/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1488679 1.00 MAP2K1 (0.62) MAP2K1MAP2K2
SCHEMBL1488292 0.89 MAP2K1 (0.55) MAP2K1MAP2K2
SCHEMBL29413521 0.89 MAP2K1 (0.55) MAP2K1MAP2K2
SCHEMBL1488582 0.88 MAP2K1 (0.54) MAP2K1MAP2K2
SCHEMBL29413514 0.88 MAP2K1 (0.54) MAP2K1MAP2K2
SCHEMBL1488056 0.85 MAP2K1 (0.55) MAP2K1MAP2K2
SCHEMBL29413374 0.85 MAP2K1 (0.55) MAP2K1MAP2K2
SCHEMBL391635 0.80 MAP2K1 (0.53) MAP2K1MAP2K2
SCHEMBL3116600 0.79 MAP2K1 (0.48) MAP2K1MAP2K2
Acetic Acid SCHEMBL22391362 0.78 MAP2K1 (0.58) MAP2K1MAP2K2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109053523-B Azetidines as MEK inhibitors for the treatment of proliferative diseases 埃克塞利希斯股份有限公司 2022-03-25 CN disclosed