Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | CNR1 | P21554 | 3/20 | 0.51 |
| ▸ | CNR2 | P34972 | 3/20 | 0.50 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29420557 | 1.00 | MAPT (0.55) | MAPTCNR1CNR2SMYD3LMNA | |
| SCHEMBL12218526 | 0.80 | GAA (0.64) | MAPTSMYD3LMNAGAAPABPC1 | |
| SCHEMBL20451349 | 0.80 | GAA (0.64) | MAPTSMYD3LMNAGAAPABPC1 | |
| SCHEMBL30044693 | 0.79 | GRM5 (0.61) | CNR1CNR2SMYD3GAAGRM5 | |
| SCHEMBL30043283 | 0.79 | GRM5 (0.61) | CNR1CNR2SMYD3GAAGRM5 | |
| SCHEMBL30043552 | 0.79 | GRM5 (0.61) | CNR1CNR2SMYD3GAAGRM5 | |
| SCHEMBL28266316 | 0.78 | SMYD3 (0.66) | MAPTSMYD3LMNAGAAPABPC1 | |
| SCHEMBL1535206 | 0.78 | SMYD3 (0.74) | MAPTSMYD3LMNAGAAPABPC1 | |
| SCHEMBL28181197 | 0.77 | SMYD3 (0.53) | MAPTSMYD3LMNAPABPC1GRM5 | |
| SCHEMBL14368736 | 0.77 | MAPT (0.49) | MAPTCNR2SMYD3LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112074505-B | Aminopyrazine diol compounds as PI 3K-gamma inhibitors | 因赛特公司 | 2024-04-05 | — | — | CN | claimed |
| EP-3762368-B1 | AMINOPYRAZINE DIOL COMPOUNDS AS PI3K-Y INHIBITORS | INCYTE CORP (US) | 2022-01-26 | — | — | EP | claimed |
| CN-112074505-B | Aminopyrazine diol compounds as PI 3K-gamma inhibitors | 因赛特公司 | 2024-04-05 | — | — | CN | disclosed |