Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 6/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.40 |
| ▸ | JAK1 | P23458 | 7/20 | 0.39 |
| ▸ | JAK3 | P52333 | 7/20 | 0.39 |
| ▸ | JAK2 | O60674 | 6/20 | 0.39 |
| ▸ | TYK2 | P29597 | 5/20 | 0.39 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1080985 | 0.83 | JAK3 (0.47) | MAPK10MAPK9MAPK8JAK1JAK3 | |
| SCHEMBL1204135 | 0.81 | MAPK10 (0.49) | MAPK10MAPK9MAPK8JAK1JAK3 | |
| SCHEMBL1203926 | 0.76 | MAPK10 (0.57) | MAPK10MAPK9MAPK8JAK1JAK3 | |
| SCHEMBL2942198 | 0.75 | MAPK10 (0.44) | MAPK10MAPK9MAPK8JAK1JAK3 | |
| SCHEMBL1202544 | 0.75 | MAPK10 (0.48) | MAPK10MAPK9MAPK8JAK2STK17A | |
| SCHEMBL1203504 | 0.73 | MAPK10 (0.57) | MAPK10MAPK9MAPK8JAK2STK17A | |
| SCHEMBL1202555 | 0.72 | MAPK10 (0.68) | MAPK10MAPK9MAPK8JAK2STK17A | |
| SCHEMBL22261093 | 0.71 | JAK3 (0.62) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL26970335 | 0.71 | JAK1 (0.57) | JAK1JAK3JAK2TYK2PIM1 | |
| SCHEMBL24625782 | 0.70 | EGFR (0.45) | MAPK10MAPK9MAPK8PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-B1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON INC (US) | 2015-08-05 | — | — | EP | disclosed |
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |