Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 10/20 | 1.00 |
| ▸ | JAK2 | O60674 | 17/20 | 0.87 |
| ▸ | AXL | P30530 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2396354 | 1.00 | JAK1 (1.00) | JAK1JAK2AXL | |
| SCHEMBL2396408 | 0.93 | JAK2 (1.00) | JAK1JAK2AXL | |
| SCHEMBL30230695 | 0.93 | JAK2 (1.00) | JAK1JAK2AXL | |
| SCHEMBL2394455 | 0.92 | JAK2 (1.00) | JAK1JAK2 | |
| SCHEMBL29422139 | 0.92 | JAK2 (1.00) | JAK1JAK2 | |
| SCHEMBL2395471 | 0.91 | JAK2 (1.00) | JAK1JAK2 | |
| SCHEMBL29422075 | 0.91 | JAK2 (1.00) | JAK1JAK2 | |
| SCHEMBL29422165 | 0.91 | JAK2 (1.00) | JAK1JAK2 | |
| SCHEMBL2394544 | 0.91 | JAK2 (1.00) | JAK1JAK2 | |
| SCHEMBL2393622 | 0.90 | JAK2 (1.00) | JAK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4400172-A2 | PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS | Incyte Holdings Corporation (US) | 2024-07-17 | — | — | EP | disclosed |
| US-20230043959-A1 | PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS | INCYTE CORPORATION | 2023-02-09 | — | — | US | disclosed |
| US-11285140-B2 | Piperidin-4-yl azetidine derivatives as JAK1 inhibitors | INCYTE CORPORATION (US) | 2022-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11285140-B2 | Piperidin-4-yl azetidine derivatives as JAK1 inhibitors | JAK1, JAK2, JAK3 | JAK1 1/4885JAK2 2/4885AXL 2549/4885 |
| US-20230043959-A1 | PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS | JAK1, JAK2, JAK3 | JAK1 1/4885JAK2 2/4885AXL 2691/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.