Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22695582 | 1.00 | MAP4K1 (0.41) | MAP4K1 | |
| SCHEMBL22695459 | 0.86 | MAP4K1 (0.43) | MAP4K1 | |
| SCHEMBL22803218 | 0.79 | MAP4K1 (0.40) | MAP4K1 | |
| SCHEMBL22691553 | 0.72 | MAP4K1 (0.43) | MAP4K1 | |
| SCHEMBL27371386 | 0.70 | MAP4K1 (0.33) | MAP4K1 | |
| SCHEMBL20517531 | 0.70 | MAP4K1 (0.44) | MAP4K1 | |
| SCHEMBL26491783 | 0.69 | MAP4K1 (0.32) | MAP4K1 | |
| SCHEMBL21353418 | 0.69 | AKR1B1 (0.33) | MAP4K1 | |
| SCHEMBL30648788 | 0.68 | — | — | |
| SCHEMBL29516134 | 0.68 | AKR1B1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4522618-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES COMPOUNDS AS HPK1 INHIBITORS | Merck Patent GmbH (DE) | 2025-03-19 | — | — | EP | disclosed |
| WO-2023220541-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES COMPOUNDS AS HPK1 INHIBITORS | MERCK PATENT GMBH (DE) | 2023-11-16 | — | — | WO | disclosed |
| EP-3972695-A1 | SUBSTITUTED EXO-METHYLENE-OXINDOLES WHICH ARE HPK1/MAP4K1 INHIBITORS | Gilead Sciences, Inc. (US) | 2022-03-30 | — | — | EP | disclosed |