Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 9/20 | 0.61 |
| ▸ | TDO2 | P48775 | 9/20 | 0.61 |
| ▸ | FBP1 | P09467 | 1/20 | 0.47 |
| ▸ | EIF4A3 | P38919 | 3/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | PDE1A | P54750 | 1/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22394993 | 1.00 | IDO1 (0.61) | IDO1TDO2FBP1EIF4A3HRH4 | |
| SCHEMBL29974758 | 0.85 | IDO1 (0.75) | IDO1TDO2EIF4A3HRH4KDM4E | |
| SCHEMBL22747188 | 0.85 | IDO1 (0.75) | IDO1TDO2EIF4A3HRH4KDM4E | |
| SCHEMBL22620768 | 0.84 | IDO1 (0.47) | IDO1TDO2FBP1HRH4KDM4E | |
| SCHEMBL24021130 | 0.81 | EIF4A3 (0.49) | IDO1TDO2FBP1EIF4A3KDM4E | |
| SCHEMBL20505032 | 0.81 | IDO1 (0.65) | IDO1TDO2EIF4A3HRH4KDM4E | |
| SCHEMBL30817202 | 0.78 | EIF4A3 (0.62) | IDO1TDO2FBP1EIF4A3HRH4 | |
| SCHEMBL22396294 | 0.78 | IDO1 (0.65) | IDO1TDO2EIF4A3HRH4KDM4E | |
| SCHEMBL22394891 | 0.78 | IDO1 (0.65) | IDO1TDO2EIF4A3HRH4GRIN1 | |
| SCHEMBL1144985 | 0.77 | KDM4E (0.77) | IDO1TDO2FBP1EIF4A3HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3962914-A1 | NOVEL INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV) | AiCuris GmbH & Co. KG (DE) | 2022-03-09 | — | — | EP | disclosed |