Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 2/20 | 0.45 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29426497 | 1.00 | TSHR (0.47) | TSHRCASP3NLRP3AKR1B1CYP1A2 | |
| SCHEMBL26733142 | 1.00 | TSHR (0.47) | TSHRCASP3NLRP3AKR1B1CYP1A2 | |
| SCHEMBL26733141 | 0.95 | TSHR (0.50) | TSHRCASP3NLRP3AKR1B1CYP1A2 | |
| SCHEMBL29426482 | 0.92 | TSHR (0.45) | TSHRCASP3NLRP3AKR1B1CYP1A2 | |
| SCHEMBL26733005 | 0.92 | TSHR (0.45) | TSHRCASP3NLRP3AKR1B1CYP1A2 | |
| SCHEMBL26733144 | 0.91 | TSHR (0.48) | TSHRCASP3NLRP3AKR1B1CYP1A2 | |
| SCHEMBL29426511 | 0.91 | TSHR (0.48) | TSHRCASP3NLRP3AKR1B1CYP1A2 | |
| SCHEMBL29426478 | 0.89 | TSHR (0.44) | TSHRCASP3NLRP3AKR1B1CYP1A2 | |
| SCHEMBL29426476 | 0.89 | TSHR (0.44) | TSHRCASP3NLRP3AKR1B1CYP1A2 | |
| SCHEMBL26733029 | 0.89 | TSHR (0.44) | TSHRCASP3NLRP3AKR1B1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4196125-A1 | COMPOUNDS, COMPOSITIONS AND METHODS | Denali Therapeutics Inc. (US) | 2023-06-21 | — | — | EP | disclosed |
| WO-2022036204-A1 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2022-02-17 | — | — | WO | disclosed |