Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 19/20 | 0.48 |
| ▸ | BRAF | P15056 | 14/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | ARAF | P10398 | 1/20 | 0.44 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.44 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22612950 | 1.00 | RAF1 (0.48) | RAF1BRAFPDGFRBARAFDDR1 | |
| SCHEMBL29427274 | 0.88 | RAF1 (0.59) | RAF1BRAF | |
| SCHEMBL22612883 | 0.88 | RAF1 (0.59) | RAF1BRAF | |
| SCHEMBL22612833 | 0.86 | RAF1 (0.56) | RAF1BRAFPDGFRBARAFDDR1 | |
| SCHEMBL29427242 | 0.86 | RAF1 (0.56) | RAF1BRAFPDGFRBARAFDDR1 | |
| SCHEMBL22612725 | 0.85 | RAF1 (0.55) | RAF1BRAF | |
| SCHEMBL29427269 | 0.85 | RAF1 (0.55) | RAF1BRAF | |
| SCHEMBL22612733 | 0.84 | RAF1 (0.51) | RAF1BRAF | |
| SCHEMBL29427268 | 0.84 | RAF1 (0.51) | RAF1BRAF | |
| SCHEMBL22625518 | 0.83 | RAF1 (0.50) | RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3962484-A1 | INHIBITORS OF RAF KINASES | Kinnate Biopharma Inc. (US) | 2022-03-09 | — | — | EP | disclosed |