Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 5/20 | 0.46 |
| ▸ | BRAF | P15056 | 6/20 | 0.45 |
| ▸ | KDR | P35968 | 5/20 | 0.45 |
| ▸ | KRAS | P01116 | 4/20 | 0.45 |
| ▸ | SRC | P12931 | 3/20 | 0.45 |
| ▸ | ABL1 | P00519 | 2/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | ARAF | P10398 | 1/20 | 0.45 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.45 |
| ▸ | CSK | P41240 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.45 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.45 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.45 |
| ▸ | MAP3K1 | Q13233 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29427284 | 1.00 | RAF1 (0.46) | RAF1BRAFKDRKRASSRC | |
| SCHEMBL22612930 | 1.00 | RAF1 (0.46) | RAF1BRAFKDRKRASSRC | |
| SCHEMBL24457876 | 0.87 | SIK2 (0.40) | RAF1BRAFKDRKRASSRC | |
| SCHEMBL24457818 | 0.85 | RAF1 (0.39) | RAF1BRAFKDRKRASSRC | |
| SCHEMBL24457802 | 0.84 | KDR (0.42) | RAF1BRAFKDRKRASSRC | |
| SCHEMBL29877852 | 0.82 | KDR (0.45) | RAF1BRAFKDRKRASABL1 | |
| SCHEMBL24457808 | 0.81 | MAP4K4 (0.56) | RAF1BRAFKDRKRASSRC | |
| SCHEMBL15269552 | 0.80 | BRAF (0.56) | RAF1BRAFKDRKRASSRC | |
| SCHEMBL24457809 | 0.80 | BRAF (0.48) | RAF1BRAFKDRKRASSRC | |
| SCHEMBL24457875 | 0.80 | BRAF (0.48) | RAF1BRAFKDRKRASSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3962484-A1 | INHIBITORS OF RAF KINASES | Kinnate Biopharma Inc. (US) | 2022-03-09 | — | — | EP | disclosed |