Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 9/20 | 0.78 |
| ▸ | NPC1 | O15118 | 1/20 | 0.67 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.62 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 5/20 | 0.60 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5941022 | 1.00 | MIF (0.78) | MIFNPC1PIK3CDPIK3CBMAPT | |
| SCHEMBL5941006 | 0.92 | MIF (0.80) | MIFNPC1PIK3CDPIK3CBMAPT | |
| SCHEMBL29427463 | 0.92 | MIF (0.80) | MIFNPC1PIK3CDPIK3CBMAPT | |
| SCHEMBL5940765 | 0.90 | MIF (0.67) | MIFNPC1PIK3CDPIK3CBMAPT | |
| SCHEMBL29427478 | 0.90 | MIF (0.68) | MIFNPC1PIK3CDPIK3CBMAPT | |
| SCHEMBL5940947 | 0.90 | MIF (0.68) | MIFNPC1PIK3CDPIK3CBMAPT | |
| SCHEMBL5940908 | 0.88 | MIF (0.69) | MIFPIK3CDPIK3CBESR2PTGS1 | |
| SCHEMBL29427503 | 0.85 | MIF (0.71) | MIFNPC1MAPTESR2MEN1 | |
| SCHEMBL5940810 | 0.85 | MIF (0.71) | MIFNPC1MAPTESR2MEN1 | |
| SCHEMBL29427499 | 0.85 | MIF (0.72) | MIFNPC1PIK3CDPIK3CBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220062242-A1 | Methods and compositions for inhibiting mutant EGFR signaling | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2022-03-03 | — | — | US | claimed |
| US-20220062242-A1 | Methods and compositions for inhibiting mutant EGFR signaling | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2022-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220062242-A1 | Methods and compositions for inhibiting mutant EGFR signaling | EGFR, ERBB2, ERBB4 | MIF 4697/4885NPC1 3421/4885PIK3CD 39/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.