Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 12/20 | 0.78 |
| ▸ | CHRM1 | P11229 | 9/20 | 0.78 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.78 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.78 |
| ▸ | CHRM4 | P08173 | 7/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18825805 | 1.00 | CHRM2 (0.78) | CHRM2CHRM1CHRM5CHRM3CHRM4 | |
| SCHEMBL18825846 | 0.89 | CHRM4 (0.79) | CHRM2CHRM1CHRM5CHRM3CHRM4 | |
| SCHEMBL29432367 | 0.89 | CHRM4 (0.79) | CHRM2CHRM1CHRM5CHRM3CHRM4 | |
| SCHEMBL18826009 | 0.88 | CHRM4 (0.72) | CHRM2CHRM1CHRM5CHRM3CHRM4 | |
| SCHEMBL23502079 | 0.87 | CHRM2 (1.00) | CHRM2CHRM1CHRM5CHRM3CHRM4 | |
| SCHEMBL29432109 | 0.87 | CHRM2 (1.00) | CHRM2CHRM1CHRM5CHRM3CHRM4 | |
| SCHEMBL18825792 | 0.87 | CHRM4 (0.76) | CHRM2CHRM1CHRM5CHRM3CHRM4 | |
| SCHEMBL29432032 | 0.87 | CHRM4 (0.76) | CHRM2CHRM1CHRM5CHRM3CHRM4 | |
| SCHEMBL23744384 | 0.87 | CHRM2 (0.59) | CHRM2CHRM1CHRM5CHRM3CHRM4 | |
| SCHEMBL18825992 | 0.86 | CHRM4 (0.72) | CHRM2CHRM1CHRM5CHRM3CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3371164-B1 | N-[2-(1-BENZYLPIPERIDIN-4-YL)ETHYL]-4-(PYRAZIN-2-YL)-PIPERAZINE-1-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS MUSCARINIC RECEPTOR 4 (M4) ANTAGONISTS FOR TREATING NEUROLOGICAL DISEASES | NEUROCRINE BIOSCIENCES INC (US) | 2022-03-16 | — | — | EP | disclosed |