Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.41 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16065930 | 1.00 | POLB (0.50) | POLBMEN1KMT2ASMN1; SMN2KEAP1 | |
| SCHEMBL12433989 | 0.89 | MEN1 (0.54) | POLBMEN1KMT2ASMN1; SMN2KEAP1 | |
| SCHEMBL10014679 | 0.82 | MEN1 (0.53) | POLBMEN1KMT2ASMN1; SMN2KEAP1 | |
| SCHEMBL3130427 | 0.81 | HIF1A (0.54) | KMT2ASMN1; SMN2HPGDTP53HTT | |
| SCHEMBL14429809 | 0.81 | HPGD (0.43) | POLBSMN1; SMN2HPGDSLC6A2SLC6A4 | |
| SCHEMBL5255270 | 0.81 | MEN1 (0.56) | POLBMEN1KMT2ASMN1; SMN2KEAP1 | |
| SCHEMBL5255263 | 0.81 | KMT2A (0.52) | POLBMEN1KMT2ASMN1; SMN2KEAP1 | |
| SCHEMBL22927819 | 0.80 | SLC6A4 (0.37) | POLBMEN1KMT2AHPGDSLC6A2 | |
| SCHEMBL4019795 | 0.79 | HPGD (0.45) | HPGD | |
| Hydrochloric Acid SCHEMBL29444036 | 0.79 | HIF1A (0.53) | KMT2AHPGDTP53HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114174290-A | Modulators of TREX1 | 星座制药公司 | 2022-03-11 | — | — | CN | disclosed |