Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 1/20 | 0.44 |
| ▸ | YAP1 | P46937 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TYK2 | P29597 | 2/20 | 0.37 |
| ▸ | SYK | P43405 | 2/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | ROS1 | P08922 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | FER | P16591 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | CLK2 | P49760 | 1/20 | 0.37 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22718031 | 1.00 | TEAD1 (0.44) | TEAD1YAP1MEN1KMT2ATYK2 | |
| SCHEMBL29438846 | 0.89 | TEAD1 (0.45) | TEAD1YAP1MEN1KMT2AKDM4E | |
| SCHEMBL22718180 | 0.89 | TEAD1 (0.45) | TEAD1YAP1MEN1KMT2AKDM4E | |
| SCHEMBL22718156 | 0.86 | MEN1 (0.42) | TEAD1YAP1MEN1KMT2ATAS2R14 | |
| SCHEMBL29438833 | 0.86 | MEN1 (0.42) | TEAD1YAP1MEN1KMT2ATAS2R14 | |
| SCHEMBL22718289 | 0.86 | TEAD1 (0.47) | TEAD1YAP1MEN1KMT2ASYK | |
| SCHEMBL29438915 | 0.86 | TEAD1 (0.49) | TEAD1YAP1MEN1KMT2AKDM4E | |
| SCHEMBL22718251 | 0.86 | TEAD1 (0.49) | TEAD1YAP1MEN1KMT2AKDM4E | |
| SCHEMBL29438917 | 0.86 | TEAD1 (0.49) | TEAD1YAP1MEN1KMT2AKDM4E | |
| SCHEMBL29438894 | 0.86 | TEAD1 (0.47) | TEAD1YAP1MEN1KMT2ASYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119954725-A | TEAD inhibitors and uses thereof | 医肯纳肿瘤学公司 | 2025-05-09 | — | — | CN | disclosed |
| CN-114466839-B | TEAD inhibitors and uses thereof | 医肯纳肿瘤学公司 | 2025-01-07 | — | — | CN | disclosed |
| EP-3976194-A2 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-04-06 | — | — | EP | disclosed |