Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 4/20 | 0.72 |
| ▸ | YAP1 | P46937 | 1/20 | 0.72 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TLR2 | O60603 | 3/20 | 0.40 |
| ▸ | TLR1 | Q15399 | 3/20 | 0.40 |
| ▸ | TNNI3K | Q59H18 | 3/20 | 0.38 |
| ▸ | OXTR | P30559 | 1/20 | 0.36 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | ATP1A1 | P05023 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29438888 | 1.00 | TEAD1 (0.72) | TEAD1YAP1TSHRL3MBTL1TLR2 | |
| SCHEMBL22718346 | 1.00 | TEAD1 (0.72) | TEAD1YAP1TSHRL3MBTL1TLR2 | |
| SCHEMBL22718170 | 1.00 | TEAD1 (0.72) | TEAD1YAP1TSHRL3MBTL1TLR2 | |
| SCHEMBL22718168 | 1.00 | TEAD1 (0.72) | TEAD1YAP1TSHRL3MBTL1TLR2 | |
| SCHEMBL22718186 | 0.90 | TEAD1 (0.64) | TEAD1YAP1TLR2TLR1TNNI3K | |
| SCHEMBL29438845 | 0.90 | TEAD1 (0.64) | TEAD1YAP1TLR2TLR1TNNI3K | |
| SCHEMBL29438848 | 0.90 | TEAD1 (0.64) | TEAD1YAP1TLR2TLR1TNNI3K | |
| SCHEMBL22718281 | 0.90 | TEAD1 (0.64) | TEAD1YAP1TLR2TLR1TNNI3K | |
| SCHEMBL22718187 | 0.90 | TEAD1 (0.64) | TEAD1YAP1TLR2TLR1TNNI3K | |
| SCHEMBL22718030 | 0.87 | TEAD1 (0.56) | TEAD1YAP1L3MBTL1TNNI3KEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119954725-A | TEAD inhibitors and uses thereof | 医肯纳肿瘤学公司 | 2025-05-09 | — | — | CN | disclosed |
| CN-114466839-B | TEAD inhibitors and uses thereof | 医肯纳肿瘤学公司 | 2025-01-07 | — | — | CN | disclosed |
| EP-3976194-A2 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-04-06 | — | — | EP | disclosed |