Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 19/20 | 0.70 |
| ▸ | LCK | P06239 | 6/20 | 0.70 |
| ▸ | SRC | P12931 | 2/20 | 0.70 |
| ▸ | KDR | P35968 | 1/20 | 0.70 |
| ▸ | TEK | Q02763 | 1/20 | 0.70 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.69 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.69 |
| ▸ | LYN | P07948 | 2/20 | 0.68 |
| ▸ | EGFR | P00533 | 6/20 | 0.61 |
| ▸ | ITK | Q08881 | 4/20 | 0.57 |
| ▸ | ABL1 | P00519 | 1/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.55 |
| ▸ | FYN | P06241 | 1/20 | 0.55 |
| ▸ | YES1 | P07947 | 1/20 | 0.55 |
| ▸ | HCK | P08631 | 1/20 | 0.55 |
| ▸ | FGR | P09769 | 1/20 | 0.55 |
| ▸ | FER | P16591 | 1/20 | 0.55 |
| ▸ | CSK | P41240 | 1/20 | 0.55 |
| ▸ | TEC | P42680 | 1/20 | 0.55 |
| ▸ | BLK | P51451 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22720779 | 1.00 | BTK (0.70) | BTKLCKSRCKDRTEK | |
| SCHEMBL5805229 | 0.95 | BTK (0.75) | BTKLCKSRCKDRTEK | |
| SCHEMBL22737944 | 0.90 | BTK (0.66) | BTKLCKSRCKDRTEK | |
| SCHEMBL22720761 | 0.90 | BTK (0.66) | BTKLCKSRCKDRTEK | |
| SCHEMBL29439248 | 0.90 | BTK (0.66) | BTKLCKSRCKDRTEK | |
| SCHEMBL22737541 | 0.86 | BTK (0.70) | BTKLCKSRCKDRTEK | |
| SCHEMBL5823929 | 0.86 | BTK (0.61) | BTKLCKSRCKDRTEK | |
| SCHEMBL5804616 | 0.86 | BTK (0.93) | BTKLCKSRCKDRTEK | |
| Hydrochloric Acid SCHEMBL22720961 | 0.86 | BTK (0.69) | BTKLCKSRCKDRTEK | |
| SCHEMBL6431135 | 0.86 | BTK (0.78) | BTKLCKSRCKDRTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118027041-A | BTK inhibitor ring derivative and preparation method and pharmaceutical application thereof | 西藏海思科制药有限公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-113544130-B | BTK inhibitor ring derivative and preparation method and pharmaceutical application thereof | 西藏海思科制药有限公司 | 2024-01-09 | — | — | CN | disclosed |
| EP-3978496-A1 | BTK INHIBITOR RING DERIVATIVE, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL APPLICATION THEREOF | Haisco Pharmaceuticals Pte. Ltd. (SG) | 2022-04-06 | — | — | EP | disclosed |