Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | AHR | P35869 | 2/20 | 0.40 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | BLM | P54132 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.34 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1613102 | 1.00 | SMN1; SMN2 (0.55) | SMN1; SMN2L3MBTL1AHRMAP3K14CHRM2 | |
| SCHEMBL15193140 | 1.00 | SMN1; SMN2 (0.55) | SMN1; SMN2L3MBTL1AHRMAP3K14CHRM2 | |
| SCHEMBL29472057 | 1.00 | SMN1; SMN2 (0.55) | SMN1; SMN2L3MBTL1AHRMAP3K14CHRM2 | |
| SCHEMBL15192459 | 1.00 | SMN1; SMN2 (0.55) | SMN1; SMN2L3MBTL1AHRMAP3K14CHRM2 | |
| SCHEMBL2068478 | 0.81 | SMN1; SMN2 (0.55) | SMN1; SMN2L3MBTL1AHRMAP3K14CHRM2 | |
| SCHEMBL8202058 | 0.80 | SMN1; SMN2 (0.48) | SMN1; SMN2L3MBTL1AHRCHRM2ALDH1A1 | |
| SCHEMBL16522722 | 0.79 | SMN1; SMN2 (0.53) | SMN1; SMN2L3MBTL1AHRMAP3K14CHRM2 | |
| SCHEMBL16526478 | 0.79 | SMN1; SMN2 (0.53) | SMN1; SMN2L3MBTL1AHRMAP3K14CHRM2 | |
| SCHEMBL6921056 | 0.77 | SMN1; SMN2 (0.67) | SMN1; SMN2L3MBTL1AHRCHRM2CHRM3 | |
| SCHEMBL946635 | 0.77 | SMN1; SMN2 (0.67) | SMN1; SMN2L3MBTL1AHRCHRM2CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118908957-A | Small molecule inhibitors of NF- κB induced kinase | 詹森药业有限公司 | 2024-11-08 | — | — | CN | disclosed |
| CN-114222737-B | Small molecule inhibitors of NF- κB induced kinase | 詹森药业有限公司 | 2024-07-26 | — | — | CN | disclosed |
| EP-3976597-A1 | SMALL MOLECULE INHIBITORS OF NF-KB INDUCING KINASE | Janssen Pharmaceutica NV (BE) | 2022-04-06 | — | — | EP | disclosed |
| CN-114222737-A | Small molecule inhibitor of NF-kB induced kinase | 詹森药业有限公司 | 2022-03-22 | — | — | CN | disclosed |