Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CHKA | P35790 | 1/20 | 0.34 |
| ▸ | HSP90B1 | P14625 | 6/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | CLK1 | P49759 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.31 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22715334 | 1.00 | CDC7 (0.39) | CDC7DBF4MAP4K4CA2CHKA | |
| SCHEMBL29439817 | 0.77 | ADORA2A (0.37) | MAP4K4HSP90B1PIK3CDCLK1PDE5A | |
| SCHEMBL22715627 | 0.77 | ADORA2A (0.37) | MAP4K4HSP90B1PIK3CDCLK1PDE5A | |
| SCHEMBL22715698 | 0.74 | CDC7 (0.40) | CDC7DBF4MAP4K4HSP90B1PDE5A | |
| SCHEMBL29439648 | 0.74 | CDC7 (0.40) | CDC7DBF4MAP4K4HSP90B1PDE5A | |
| SCHEMBL28936453 | 0.74 | PIK3CG (0.40) | MAP4K4HSP90B1PDE5AHSP90AA1TRAP1 | |
| SCHEMBL22715904 | 0.74 | ADORA2A (0.39) | MAP4K4HSP90B1CLK1PDE5AHSP90AA1 | |
| SCHEMBL29439732 | 0.74 | ADORA2A (0.39) | MAP4K4HSP90B1CLK1PDE5AHSP90AA1 | |
| SCHEMBL22716370 | 0.73 | MAP4K4 (0.33) | MAP4K4HSP90B1PDE5AHSP90AA1TRAP1 | |
| SCHEMBL30762108 | 0.73 | PDE5A (0.41) | CDC7DBF4MAP4K4CA2CHKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118908957-A | Small molecule inhibitors of NF- κB induced kinase | 詹森药业有限公司 | 2024-11-08 | — | — | CN | disclosed |
| CN-114222737-B | Small molecule inhibitors of NF- κB induced kinase | 詹森药业有限公司 | 2024-07-26 | — | — | CN | disclosed |
| EP-3976597-A1 | SMALL MOLECULE INHIBITORS OF NF-KB INDUCING KINASE | Janssen Pharmaceutica NV (BE) | 2022-04-06 | — | — | EP | disclosed |
| CN-114222737-A | Small molecule inhibitor of NF-kB induced kinase | 詹森药业有限公司 | 2022-03-22 | — | — | CN | disclosed |