Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 11/20 | 0.76 |
| ▸ | FYN | P06241 | 2/20 | 0.69 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.61 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.61 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.56 |
| ▸ | DYRK2 | Q92630 | 5/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.56 |
| ▸ | CDK2 | P24941 | 4/20 | 0.56 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.56 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.56 |
| ▸ | DYRK1B | Q9Y463 | 4/20 | 0.56 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.56 |
| ▸ | CDK9 | P50750 | 3/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.55 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.52 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.51 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.51 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13234372 | 0.87 | PIM1 (0.74) | PIM1FYNPIK3CDPIK3R1MKNK1 | |
| SCHEMBL13223428 | 0.87 | FYN (0.63) | PIM1FYNPIK3CDPIK3R1DYRK1A | |
| SCHEMBL2945203 | 0.85 | PIM1 (0.71) | PIM1FYNPIK3CDPIK3R1DYRK1A | |
| SCHEMBL2943040 | 0.85 | PIK3CD (0.70) | PIM1FYNPIK3CDPIK3R1MKNK1 | |
| SCHEMBL2951158 | 0.84 | MKNK1 (0.74) | PIM1FYNDYRK1ADYRK2CCNA2 | |
| SCHEMBL2943833 | 0.82 | FYN (0.71) | PIM1FYNDYRK1ADYRK2CCNA2 | |
| SCHEMBL2945964 | 0.82 | FYN (1.00) | PIM1FYNDYRK1ADYRK2CCNA2 | |
| SCHEMBL2942575 | 0.82 | PIM1 (0.66) | PIM1FYNPIK3CDPIK3R1MKNK1 | |
| SCHEMBL19466778 | 0.82 | FYN (0.62) | PIM1FYNDYRK1ADYRK2CCNA2 | |
| SCHEMBL1054752 | 0.82 | PIK3CD (0.72) | PIM1FYNPIK3CDPIK3R1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7750000-B2 | Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments | BAYER SCHERING PHARMA AG (DE) | 2010-07-06 | — | — | US | disclosed |
| US-7750000-B2 | Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments | BAYER SCHERING PHARMA AG (DE) | 2010-07-06 | — | — | US | disclosed |
| US-20070093490-A1 | Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2007-04-26 | — | — | US | disclosed |
| US-20070093490-A1 | Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2007-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070093490-A1 | Substituted imidazo[1,2b]pyridazines as kinase inhibitors, their preparation and use as medicaments | MAP4K2, MAP3K1, MAP3K2 | PIM1 365/4885FYN 421/4885PIK3CD 101/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.