Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 9/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | STAT6 | P42226 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24276889 | 1.00 | NISCH (0.44) | NISCHMAOAMAOBCYP3A4TP53 | |
| SCHEMBL29445032 | 0.90 | NISCH (0.42) | NISCHMAOAMAOBCYP3A4TP53 | |
| SCHEMBL29445061 | 0.90 | NISCH (0.42) | NISCHMAOAMAOBCYP3A4TP53 | |
| SCHEMBL24277800 | 0.90 | NISCH (0.42) | NISCHMAOAMAOBCYP3A4TP53 | |
| SCHEMBL24277217 | 0.90 | NISCH (0.42) | NISCHMAOAMAOBCYP3A4TP53 | |
| SCHEMBL24277076 | 0.90 | NISCH (0.42) | NISCHMAOAMAOBCYP3A4TP53 | |
| SCHEMBL29445088 | 0.90 | NISCH (0.43) | NISCHMAOAMAOBCYP3A4ADRA1A | |
| SCHEMBL24277257 | 0.90 | NISCH (0.43) | NISCHMAOAMAOBCYP3A4ADRA1A | |
| SCHEMBL24277023 | 0.90 | NISCH (0.41) | NISCHMAOAMAOBCYP3A4TP53 | |
| SCHEMBL24277247 | 0.89 | NISCH (0.46) | NISCHMAOAMAOBCYP3A4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4210703-A1 | SMALL MOLECULES THAT TARGET THE RNA THAT CAUSES ALS | Expansion Therapeutics, Inc. (US) | 2023-07-19 | — | — | EP | disclosed |
| WO-2022055922-A1 | SMALL MOLECULES THAT TARGET THE RNA THAT CAUSES ALS | EXPANSION THERAPEUTICS, INC. (US) | 2022-03-17 | — | — | WO | disclosed |