Sugi Predict

Sugi Predict / Compounds / Sacubitril

Sacubitril

Sacubitril

SCHEMBL29445853

CCOC(=O)[C@H](C)C[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)CCC(=O)O.N.[K+]

nearest known ligand 0.74

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

MME

The experimentally established mechanism targets of Sacubitril. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ MME known ✓ P08473 13/20 0.74
▸ ACE P12821 4/20 0.74
▸ MMEL1 Q495T6 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Sacubitril SCHEMBL21239958 0.99 MME (0.76) MMEACEMMEL1
Sacubitril SCHEMBL21239955 0.99 MME (0.76) MMEACEMMEL1
Sacubitril SCHEMBL28709358 0.98 MME (0.74) MMEACEMMEL1
Sacubitril SCHEMBL28709357 0.98 MME (0.74) MMEACEMMEL1
Sacubitril SCHEMBL18059568 0.98 MME (0.77) MMEACEMMEL1
Sacubitril SCHEMBL22420467 0.98 MME (0.77) MMEACEMMEL1
Sacubitril SCHEMBL18574632 0.98 MME (0.77) MMEACEMMEL1
Sacubitril SCHEMBL2707112 0.98 MME (0.77) MMEACEMMEL1
Sacubitril SCHEMBL18059569 0.98 MME (0.77) MMEACEMMEL1
Sacubitril SCHEMBL8214132 0.98 MME (0.77) MMEACEMMEL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110237071-B Pharmaceutical preparation and use thereof 武汉朗来科技发展有限公司 2022-03-22 — — CN claimed
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