Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 5/20 | 0.59 |
| ▸ | TSHR | P16473 | 7/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24324040 | 1.00 | PLK1 (0.59) | PLK1TSHRGAASMN1; SMN2HSD17B10 | |
| SCHEMBL26851612 | 0.93 | PLK1 (0.52) | PLK1TSHRGAASMN1; SMN2HSD17B10 | |
| SCHEMBL29446367 | 0.92 | PLK1 (0.56) | PLK1TSHRGAASMN1; SMN2HSD17B10 | |
| SCHEMBL29446345 | 0.92 | PLK1 (0.60) | PLK1TSHRGAASMN1; SMN2HSD17B10 | |
| SCHEMBL24324794 | 0.92 | PLK1 (0.60) | PLK1TSHRGAASMN1; SMN2HSD17B10 | |
| SCHEMBL26851696 | 0.90 | PLK1 (0.58) | PLK1TSHRGAASMN1; SMN2HSD17B10 | |
| SCHEMBL29446474 | 0.89 | TSHR (0.61) | PLK1TSHRGAASMN1; SMN2HSD17B10 | |
| SCHEMBL26851738 | 0.89 | TSHR (0.61) | PLK1TSHRGAASMN1; SMN2HSD17B10 | |
| SCHEMBL24324355 | 0.89 | PLK1 (0.51) | PLK1TSHRGAASMN1; SMN2HSD17B10 | |
| SCHEMBL24324353 | 0.88 | PLK1 (0.46) | PLK1TSHRGAASMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4216958-A2 | PLK1 POLO BOX DOMAIN INHIBITORS AND METHOD OF TREATING CANCER | The United States of America, as represented by the Secretary, Department of Health and Human Services (US) | 2023-08-02 | — | — | EP | disclosed |
| WO-2022067100-A2 | PLK1 POLO BOX DOMAIN INHIBITOR AND METHOD OF TREATING CANCER | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2022-03-31 | — | — | WO | disclosed |