Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 20/20 | 0.76 |
| ▸ | APOBEC3G | Q9HC16 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26851689 | 1.00 | PLK1 (0.76) | PLK1APOBEC3GNPC1GAA | |
| SCHEMBL29446335 | 0.86 | PLK1 (1.00) | PLK1APOBEC3GNPC1GAA | |
| SCHEMBL24324406 | 0.86 | PLK1 (1.00) | PLK1APOBEC3GNPC1GAA | |
| SCHEMBL24324376 | 0.85 | PLK1 (1.00) | PLK1APOBEC3GNPC1GAA | |
| SCHEMBL24324351 | 0.85 | PLK1 (0.87) | PLK1APOBEC3GNPC1GAA | |
| SCHEMBL24324354 | 0.84 | PLK1 (0.69) | PLK1APOBEC3GGAA | |
| SCHEMBL29446391 | 0.84 | PLK1 (0.69) | PLK1APOBEC3GGAA | |
| SCHEMBL26851614 | 0.84 | PLK1 (0.87) | PLK1APOBEC3GNPC1GAA | |
| SCHEMBL24324352 | 0.84 | PLK1 (0.76) | PLK1APOBEC3GNPC1GAA | |
| SCHEMBL26851713 | 0.84 | PLK1 (0.72) | PLK1APOBEC3GNPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4216958-A2 | PLK1 POLO BOX DOMAIN INHIBITORS AND METHOD OF TREATING CANCER | The United States of America, as represented by the Secretary, Department of Health and Human Services (US) | 2023-08-02 | — | — | EP | disclosed |
| WO-2022067100-A2 | PLK1 POLO BOX DOMAIN INHIBITOR AND METHOD OF TREATING CANCER | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2022-03-31 | — | — | WO | disclosed |