Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | EDNRA | P25101 | 2/20 | 0.44 |
| ▸ | EDNRB | P24530 | 1/20 | 0.42 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | PTPN2 | P17706 | 3/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.38 |
| ▸ | PTPN5 | P54829 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11220197 | 0.77 | MAPT (0.52) | ALDH1A1TP53TDP1EDNRAEDNRB | |
| SCHEMBL5467148 | 0.72 | BACE1 (0.39) | ALDH1A1MAPTBACE1KDM4E | |
| SCHEMBL7391015 | 0.72 | BACE1 (0.44) | ALDH1A1BACE1PKMKDM4EHPGD | |
| SCHEMBL22498312 | 0.70 | CA12 (0.43) | ALDH1A1MAPTPKMPOLBHTT | |
| SCHEMBL4680048 | 0.70 | BACE1 (0.40) | ALDH1A1BACE1KDM4EPOLB | |
| SCHEMBL20558194 | 0.70 | BACE1 (0.38) | BACE1 | |
| SCHEMBL30703393 | 0.69 | BACE1 (0.39) | MAPTBACE1HPGD | |
| SCHEMBL25897373 | 0.69 | BACE1 (0.39) | MAPTBACE1HPGD | |
| SCHEMBL29387450 | 0.68 | BACE1 (0.48) | MAPTBACE1HPGD | |
| SCHEMBL15389825 | 0.68 | BACE1 (0.42) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3947344-A1 | AMINOGUANIDINE HYDRAZONES AS RETROMER STABILIZERS USEFUL FOR TREATING NEUROLOGICAL DISEASES | Ospedale San Raffaele Srl (IT) | 2022-02-09 | — | — | EP | disclosed |