Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 3/20 | 0.50 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22777793 | 1.00 | DHODH (0.50) | DHODHBCL2L1TP53CYP1A2CYP2C19 | |
| SCHEMBL22777777 | 0.78 | PLK4 (0.47) | BCL2L1HSD17B10PLK4AURKADAPK3 | |
| SCHEMBL22777736 | 0.78 | F9 (0.67) | BCL2L1PLK4AURKADAPK3CHEK2 | |
| SCHEMBL121331 | 0.78 | F9 (0.67) | BCL2L1PLK4AURKADAPK3CHEK2 | |
| SCHEMBL22777732 | 0.77 | BCL2L1 (0.51) | DHODHBCL2L1PLK4AURKADAPK3 | |
| SCHEMBL29448037 | 0.77 | BCL2L1 (0.51) | DHODHBCL2L1PLK4AURKADAPK3 | |
| SCHEMBL29448076 | 0.75 | HDAC1 (0.58) | DHODHKDM4ELMNASMN1; SMN2RAB9A | |
| SCHEMBL22777816 | 0.75 | HDAC1 (0.58) | DHODHKDM4ELMNASMN1; SMN2RAB9A | |
| SCHEMBL13133309 | 0.74 | ESR2 (0.44) | DYRK1ANR1H4SMN1; SMN2RAB9ANFKB1 | |
| SCHEMBL15697540 | 0.74 | BCL2L1 (0.66) | BCL2L1PLK4AURKADAPK3CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114222729-A | Amino acid transport inhibitors and uses thereof | 范德比尔特大学 | 2022-03-22 | — | — | CN | claimed |
| US-20220304984-A1 | AMINO ACID TRANSPORT INHIBITORS AND THE USES THEREOF | VANDERBILT UNIVERSITY | 2022-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220304984-A1 | AMINO ACID TRANSPORT INHIBITORS AND THE USES THEREOF | SLC1A5, SLC7A11, SLC3A2 | DHODH 849/4885BCL2L1 4377/4885TP53 730/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.