Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | HSP90AA1 | P07900 | 9/20 | 0.54 |
| ▸ | HSP90B1 | P14625 | 8/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.48 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.47 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3878893 | 1.00 | MAPT (0.64) | MAPTHSP90AA1HSP90B1PDGFRBESR2 | |
| SCHEMBL27233890 | 0.90 | MAPT (0.53) | MAPTHSP90AA1HSP90B1PDGFRBESR2 | |
| SCHEMBL13028051 | 0.89 | DDB1 (0.52) | MAPTHSP90AA1HSP90B1PDGFRBESR2 | |
| SCHEMBL22892388 | 0.85 | MAPT (0.59) | MAPTHSP90AA1HSP90B1ESR2NR1H2 | |
| SCHEMBL25574538 | 0.85 | MAPT (0.67) | MAPTHSP90AA1HSP90B1PDGFRBESR2 | |
| SCHEMBL4869824 | 0.85 | MAPT (0.67) | MAPTHSP90AA1HSP90B1PDGFRBESR2 | |
| SCHEMBL30378007 | 0.85 | MAPT (0.67) | MAPTHSP90AA1HSP90B1PDGFRBESR2 | |
| SCHEMBL19475563 | 0.84 | MAPT (0.65) | MAPTHSP90AA1PDGFRBESR2NR1H2 | |
| SCHEMBL3530060 | 0.84 | MAPT (0.65) | MAPTPDGFRBESR2NR1H2DDB1 | |
| SCHEMBL29757600 | 0.84 | MAPT (0.65) | MAPTHSP90AA1PDGFRBESR2NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110088104-B | Tetrahydropyridopyrimidine compounds for the treatment and prevention of hepatitis B virus infection | 豪夫迈·罗氏有限公司 | 2022-04-12 | — | — | CN | disclosed |