Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 0.81 |
| ▸ | BRAF | P15056 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19233275 | 1.00 | KDR (0.81) | KDRBRAFPOLB | |
| SCHEMBL19233210 | 0.95 | KDR (0.81) | KDRBRAF | |
| SCHEMBL19233419 | 0.94 | KDR (0.81) | KDRBRAF | |
| SCHEMBL29448729 | 0.90 | KDR (0.81) | KDRBRAF | |
| SCHEMBL19233546 | 0.90 | KDR (0.81) | KDRBRAF | |
| SCHEMBL29448682 | 0.89 | KDR (0.80) | KDR | |
| SCHEMBL19233198 | 0.89 | KDR (0.80) | KDR | |
| SCHEMBL19233405 | 0.89 | KDR (0.81) | KDRBRAF | |
| SCHEMBL29448728 | 0.89 | KDR (0.81) | KDRBRAF | |
| SCHEMBL19233292 | 0.87 | KDR (0.79) | KDRBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3412670-B1 | PYRIDINE DERIVATIVES INHIBITING RAF KINASE AND VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR, PHARMACEUTICAL COMPOSITION CONTAINING THEM AND USE THEREOF | SAMJIN PHARM CO LTD (KR) | 2022-03-09 | — | — | EP | claimed |
| EP-3412670-B1 | PYRIDINE DERIVATIVES INHIBITING RAF KINASE AND VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR, PHARMACEUTICAL COMPOSITION CONTAINING THEM AND USE THEREOF | SAMJIN PHARM CO LTD (KR) | 2022-03-09 | — | — | EP | disclosed |