Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 10/20 | 0.71 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.53 |
| ▸ | LCK | P06239 | 3/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.53 |
| ▸ | TEK | Q02763 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.52 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.52 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.52 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | BTK | Q06187 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19233279 | 1.00 | RXFP1 (0.71) | RXFP1P2RX1LCKKDRTEK | |
| SCHEMBL14410670 | 0.88 | RXFP1 (0.57) | RXFP1P2RX1KDRPTGS1P2RX4 | |
| SCHEMBL20577951 | 0.87 | RXFP1 (0.54) | RXFP1LCKKDRTEK | |
| SCHEMBL30042580 | 0.87 | RXFP1 (0.73) | RXFP1SMN1; SMN2MAPTCYP3A4CYP2C19 | |
| SCHEMBL1013325 | 0.87 | RXFP1 (0.73) | RXFP1SMN1; SMN2MAPTCYP3A4CYP2C19 | |
| SCHEMBL29448791 | 0.84 | RXFP1 (0.55) | RXFP1P2RX1KDRP2RX4P2RX7 | |
| SCHEMBL20578118 | 0.83 | RXFP1 (0.60) | RXFP1KDRSMN1; SMN2MAPT | |
| SCHEMBL20577892 | 0.83 | P2RX1 (0.60) | RXFP1P2RX1LCKKDRTEK | |
| SCHEMBL15528675 | 0.83 | RXFP1 (1.00) | RXFP1 | |
| SCHEMBL29716027 | 0.83 | RXFP1 (1.00) | RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3412670-B1 | PYRIDINE DERIVATIVES INHIBITING RAF KINASE AND VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR, PHARMACEUTICAL COMPOSITION CONTAINING THEM AND USE THEREOF | SAMJIN PHARM CO LTD (KR) | 2022-03-09 | — | — | EP | disclosed |