Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.65 |
| ▸ | BRAF | P15056 | 4/20 | 0.57 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.52 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.52 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29448752 | 0.91 | KDR (0.66) | KDRBRAF | |
| SCHEMBL19233324 | 0.91 | KDR (0.66) | KDRBRAF | |
| SCHEMBL19233413 | 0.91 | KDR (0.80) | KDRBRAF | |
| SCHEMBL19233292 | 0.89 | KDR (0.79) | KDRBRAF | |
| SCHEMBL29448751 | 0.87 | KDR (0.80) | KDRBRAF | |
| SCHEMBL19233283 | 0.87 | KDR (0.80) | KDRBRAF | |
| SCHEMBL19233263 | 0.86 | KDR (0.79) | KDRBRAF | |
| SCHEMBL20577785 | 0.85 | KDR (0.58) | KDRBRAF | |
| SCHEMBL29448738 | 0.84 | KDR (0.63) | KDRBRAF | |
| SCHEMBL19233325 | 0.84 | KDR (0.63) | KDRBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3412670-B1 | PYRIDINE DERIVATIVES INHIBITING RAF KINASE AND VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR, PHARMACEUTICAL COMPOSITION CONTAINING THEM AND USE THEREOF | SAMJIN PHARM CO LTD (KR) | 2022-03-09 | — | — | EP | disclosed |