⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13991691 | 0.85 | LCK (0.37) | — | |
| SCHEMBL5615305 | 0.84 | — | — | |
| SCHEMBL8937075 | 0.82 | LCK (0.65) | — | |
| SCHEMBL25477762 | 0.80 | LCK (0.69) | — | |
| SCHEMBL11967104 | 0.80 | LCK (0.69) | — | |
| SCHEMBL8937087 | 0.80 | LCK (0.69) | — | |
| SCHEMBL29597202 | 0.80 | LCK (0.69) | — | |
| SCHEMBL287910 | 0.78 | — | — | |
| SCHEMBL8364130 | 0.78 | — | — | |
| SCHEMBL17333513 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160002185-A1 | CIS-MORPHOLINONE AND OTHER COMPOUNDS AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER | AMGEN INC. (US) | 2016-01-07 | — | — | US | disclosed |
| US-7799799-B2 | Indolizine derivatives, method for preparing same, and therapeutic compositions comprising same | SANOFI-AVENTIS (FR) | 2010-09-21 | — | — | US | disclosed |
| EP-1957490-B1 | NOVEL INDOLIZINE DERIVATIVES, METHOD FOR PREPARING SAME AND THERAPEUTIC COMPOSITIONS COMPRISING SAME | SANOFI AVENTIS (FR) | 2010-01-06 | — | — | EP | disclosed |
| US-20080287485-A1 | NOVEL INDOLIZINE DERIVATIVES, METHOD FOR PREPARING SAME, AND THERAPEUTIC COMPOSITIONS COMPRISING SAME | SANOFI-AVENTIS (FR) | 2008-11-20 | — | — | US | disclosed |
| EP-1957490-A1 | NOVEL INDOLIZINE DERIVATIVES, METHOD FOR PREPARING SAME AND THERAPEUTIC COMPOSITIONS COMPRISING SAME | sanofi-aventis (FR) | 2008-08-20 | — | — | EP | disclosed |
| US-7351727-B2 | Inhibitors of 15-lipoxygenase | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-04-01 | — | — | US | disclosed |
| US-20080004290-A1 | Anti-Cancer Agents | THE UNIVERSITY OF QUEENSLAND (AU) | 2008-01-03 | — | — | US | disclosed |
| US-20080004290-A1 | Anti-Cancer Agents | THE UNIVERSITY OF QUEENSLAND (AU) | 2008-01-03 | — | — | US | disclosed |
| WO-2007060318-A1 | NOVEL INDOLIZINE DERIVATIVES, METHOD FOR PREPARING SAME AND THERAPEUTIC COMPOSITIONS COMPRISING SAME | SANOFI-AVENTIS (FR) | 2007-05-31 | — | — | WO | disclosed |
| EP-0929506-A1 | PROCESS FOR PREPARING STILBENE DIOLS | THE DOW CHEMICAL COMPANY (US) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998011043-A1 | PROCESS FOR PREPARING STILBENE DIOLS | THE DOW CHEMICAL COMPANY (US) | 1998-03-19 | — | — | WO | disclosed |
| US-RE29843-E | Substituted thiazoles and flavoring processes and products produced thereby | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1978-11-21 | — | — | US | disclosed |