Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 17/20 | 0.78 |
| ▸ | WDR77 | Q9BQA1 | 17/20 | 0.78 |
| ▸ | RIOK1 | Q9BRS2 | 1/20 | 0.74 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29452095 | 0.91 | PRMT5 (0.88) | PRMT5WDR77RIOK1RAB9A | |
| SCHEMBL29451863 | 0.88 | PRMT5 (0.83) | PRMT5WDR77RIOK1RAB9AKDM4E | |
| SCHEMBL29451378 | 0.88 | PRMT5 (1.00) | PRMT5WDR77RIOK1RAB9A | |
| SCHEMBL29451555 | 0.88 | PRMT5 (1.00) | PRMT5WDR77RIOK1RAB9A | |
| SCHEMBL29451523 | 0.88 | PRMT5 (1.00) | PRMT5WDR77RIOK1RAB9A | |
| SCHEMBL29451723 | 0.86 | PRMT5 (0.86) | PRMT5WDR77RIOK1KDM4E | |
| SCHEMBL29451462 | 0.86 | PRMT5 (0.85) | PRMT5WDR77RIOK1 | |
| SCHEMBL29451871 | 0.85 | PRMT5 (1.00) | PRMT5WDR77RIOK1RAB9A | |
| SCHEMBL29452143 | 0.85 | PRMT5 (1.00) | PRMT5WDR77RIOK1RAB9A | |
| SCHEMBL29451346 | 0.85 | PRMT5 (0.84) | PRMT5WDR77RIOK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |