SCHEMBL29451537 — predicted protein targets

Predicted protein targets (top 16)

	gene	UniProt	supporting neighbours	confidence
▸	PRMT5	O14744	19/20	0.72

▸	WDR77	Q9BQA1	19/20	0.72

▸	RAB9A	P51151	2/20	0.57

▸	PAX8	Q06710	2/20	0.57

▸	L3MBTL1	Q9Y468	2/20	0.57

▸	NPC1	O15118	1/20	0.57

▸	MITF	O75030	1/20	0.57

▸	ALDH1A1	P00352	1/20	0.57

▸	POLB	P06746	1/20	0.57

▸	MAPT	P10636	1/20	0.57

▸	MAPK1	P28482	1/20	0.57

▸	RECQL	P46063	1/20	0.57

▸	KMT2A	Q03164	1/20	0.57

▸	MCL1	Q07820	1/20	0.57

▸	NPSR1	Q6W5P4	1/20	0.57

▸	RIOK1	Q9BRS2	1/20	0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL29452135	1.00	PRMT5 (0.72)	PRMT5WDR77RAB9APAX8L3MBTL1
SCHEMBL29451895	0.90	PRMT5 (0.75)	PRMT5WDR77RAB9APAX8L3MBTL1
SCHEMBL29451819	0.89	PRMT5 (0.63)	PRMT5WDR77RAB9APAX8L3MBTL1
SCHEMBL29451906	0.89	PRMT5 (0.72)	PRMT5WDR77RAB9APAX8L3MBTL1
SCHEMBL29451345	0.89	PRMT5 (0.72)	PRMT5WDR77RAB9APAX8L3MBTL1
SCHEMBL29451405	0.86	PRMT5 (0.74)	PRMT5WDR77KMT2ARIOK1
SCHEMBL29451909	0.86	PRMT5 (0.74)	PRMT5WDR77KMT2ARIOK1
SCHEMBL29451675	0.86	PRMT5 (0.74)	PRMT5WDR77KMT2ARIOK1
SCHEMBL29451681	0.86	PRMT5 (0.74)	PRMT5WDR77KMT2ARIOK1
SCHEMBL29451732	0.84	PRMT5 (0.70)	PRMT5WDR77RAB9APAX8L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2022032144-A1	SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF	THE BROAD INSTITUTE, INC. (US)	2022-02-10	—	—	WO	disclosed