Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 15/20 | 0.85 |
| ▸ | WDR77 | Q9BQA1 | 15/20 | 0.85 |
| ▸ | RIOK1 | Q9BRS2 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29451619 | 1.00 | PRMT5 (0.85) | PRMT5WDR77RIOK1KDM4EKMT2A | |
| SCHEMBL29451378 | 0.92 | PRMT5 (1.00) | PRMT5WDR77RIOK1 | |
| SCHEMBL29451555 | 0.92 | PRMT5 (1.00) | PRMT5WDR77RIOK1 | |
| SCHEMBL29451523 | 0.92 | PRMT5 (1.00) | PRMT5WDR77RIOK1 | |
| SCHEMBL29451518 | 0.91 | PRMT5 (0.71) | PRMT5WDR77RIOK1KDM4EKMT2A | |
| SCHEMBL29451405 | 0.86 | PRMT5 (0.74) | PRMT5WDR77RIOK1KDM4EKMT2A | |
| SCHEMBL29451909 | 0.86 | PRMT5 (0.74) | PRMT5WDR77RIOK1KDM4EKMT2A | |
| SCHEMBL29452001 | 0.86 | PRMT5 (0.69) | PRMT5WDR77RIOK1KMT2A | |
| SCHEMBL29451635 | 0.86 | PRMT5 (0.69) | PRMT5WDR77RIOK1KMT2A | |
| SCHEMBL29451758 | 0.86 | PRMT5 (0.78) | PRMT5WDR77RIOK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |