Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 2/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.34 |
| ▸ | DYRK2 | Q92630 | 6/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 6/20 | 0.34 |
| ▸ | DYRK3 | O43781 | 5/20 | 0.34 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
| ▸ | PHGDH | O43175 | 2/20 | 0.33 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.33 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23041518 | 1.00 | MME (0.37) | MMEDYRK1ADYRK2DYRK1BDYRK3 | |
| SCHEMBL23041517 | 1.00 | MME (0.37) | MMEDYRK1ADYRK2DYRK1BDYRK3 | |
| SCHEMBL23041404 | 0.93 | MME (0.38) | MMEDYRK1ADYRK2DYRK1BDYRK3 | |
| SCHEMBL29452268 | 0.93 | MME (0.38) | MMEDYRK1ADYRK2DYRK1BDYRK3 | |
| SCHEMBL23041405 | 0.93 | MME (0.38) | MMEDYRK1ADYRK2DYRK1BDYRK3 | |
| SCHEMBL23041394 | 0.90 | MME (0.36) | MMEDYRK1ADYRK2DYRK1BDYRK3 | |
| SCHEMBL23041393 | 0.90 | MME (0.36) | MMEDYRK1ADYRK2DYRK1BDYRK3 | |
| SCHEMBL23041980 | 0.90 | MME (0.36) | MMEDYRK1ADYRK2DYRK1BDYRK3 | |
| SCHEMBL23041981 | 0.90 | MME (0.36) | MMEDYRK1ADYRK2DYRK1BDYRK3 | |
| SCHEMBL29452356 | 0.90 | MME (0.36) | MMEDYRK1ADYRK2DYRK1BDYRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4021572-A1 | SUBSTITUTED 1,3-PHENYL HETEROARYL DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | Novartis AG (CH) | 2022-07-06 | — | — | EP | claimed |
| CN-114341132-A | Substituted 1, 3-phenylheteroaryl derivatives and their use in the treatment of diseases | 诺华股份有限公司 | 2022-04-12 | — | — | CN | claimed |
| EP-4021572-A1 | SUBSTITUTED 1,3-PHENYL HETEROARYL DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | Novartis AG (CH) | 2022-07-06 | — | — | EP | disclosed |
| CN-114341132-A | Substituted 1, 3-phenylheteroaryl derivatives and their use in the treatment of diseases | 诺华股份有限公司 | 2022-04-12 | — | — | CN | disclosed |