Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 10/20 | 0.65 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.61 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.61 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.61 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.61 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.61 |
| ▸ | TAAR1 | Q96RJ0 | 6/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | NAAA | Q02083 | 3/20 | 0.46 |
| ▸ | NOS1 | P29475 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4701003 | 0.80 | MIF (0.67) | MIFTRPA1CYP2E1CYP2A6HIF1A | |
| SCHEMBL13623241 | 0.78 | MIF (0.64) | MIFTRPA1CYP2E1CYP2A6HIF1A | |
| SCHEMBL659100 | 0.78 | TAAR1 (0.70) | CYP2A6HIF1ATAAR1DRD2DRD1 | |
| Phenethylisothiocyanate SCHEMBL27616786 | 0.77 | MIF (1.00) | MIFTRPA1CYP2E1CYP2A6HIF1A | |
| Phenethylisothiocyanate SCHEMBL156960 | 0.77 | MIF (1.00) | MIFTRPA1CYP2E1CYP2A6HIF1A | |
| Hydrochloric Acid SCHEMBL3957562 | 0.76 | TAAR1 (0.67) | CYP2A6HIF1ATAAR1DRD2DRD1 | |
| SCHEMBL332410 | 0.74 | MIF (0.79) | MIFTRPA1CYP2E1CYP2A6HIF1A | |
| SCHEMBL9116288 | 0.73 | MIF (0.92) | MIFTRPA1CYP2E1CYP2A6HIF1A | |
| SCHEMBL2642524 | 0.72 | TAAR1 (0.61) | CYP2A6TAAR1DRD2DRD1NOS1 | |
| SCHEMBL6804290 | 0.71 | MIF (0.50) | MIFTRPA1CYP2E1CYP2A6HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010140902-A1 | INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR | HAMPTON MARK (NZ) | 2010-12-09 | — | — | WO | claimed |
| WO-2010140902-A1 | INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR | HAMPTON MARK (NZ) | 2010-12-09 | — | — | WO | disclosed |
| WO-2010140902-A1 | INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR | HAMPTON MARK (NZ) | 2010-12-09 | — | — | WO | disclosed |