Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 20/20 | 0.77 |
| ▸ | PRKDC | P78527 | 3/20 | 0.77 |
| ▸ | GSK3B | P49841 | 1/20 | 0.77 |
| ▸ | ATM | Q13315 | 3/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13138046 | 1.00 | ATR (0.77) | ATRPRKDCGSK3BATM | |
| SCHEMBL13137986 | 1.00 | ATR (0.77) | ATRPRKDCGSK3BATM | |
| SCHEMBL13138270 | 1.00 | ATR (0.77) | ATRPRKDCGSK3BATM | |
| SCHEMBL13138931 | 0.94 | ATR (0.79) | ATRPRKDCGSK3BATM | |
| SCHEMBL13138047 | 0.89 | ATR (0.81) | ATRPRKDCGSK3BATM | |
| SCHEMBL13138228 | 0.89 | ATR (0.81) | ATRPRKDCGSK3BATM | |
| SCHEMBL2513058 | 0.87 | ATR (1.00) | ATRPRKDCGSK3BATM | |
| SCHEMBL13138172 | 0.86 | ATR (1.00) | ATRPRKDCGSK3BATM | |
| SCHEMBL2483508 | 0.86 | ATR (0.76) | ATRPRKDCGSK3BATM | |
| SCHEMBL19102112 | 0.86 | ATR (0.76) | ATRPRKDCGSK3BATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3354650-B1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | VERTEX PHARMA (US) | 2022-02-16 | — | — | EP | disclosed |