Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 20/20 | 0.47 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | PRKDC | P78527 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3059651 | 1.00 | ATR (0.47) | ATRATMPRKDCGSK3B | |
| SCHEMBL29458652 | 0.96 | ATR (0.47) | ATRATMPRKDCGSK3B | |
| SCHEMBL3052935 | 0.96 | ATR (0.47) | ATRATMPRKDCGSK3B | |
| SCHEMBL20266546 | 0.93 | ATR (0.48) | ATRATMPRKDCGSK3B | |
| SCHEMBL3057400 | 0.92 | ATR (0.52) | ATRATMPRKDCGSK3B | |
| SCHEMBL16069984 | 0.90 | ATR (0.57) | ATRATMPRKDCGSK3B | |
| SCHEMBL3052963 | 0.89 | ATR (0.49) | ATRATMPRKDCGSK3B | |
| SCHEMBL3046787 | 0.88 | ATR (0.47) | ATRATMPRKDCGSK3B | |
| SCHEMBL20433688 | 0.88 | ATR (0.47) | ATRATMPRKDCGSK3B | |
| SCHEMBL29458710 | 0.88 | ATR (0.47) | ATRATMPRKDCGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3354650-B1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | VERTEX PHARMA (US) | 2022-02-16 | — | — | EP | disclosed |