SCHEMBL2945872

SCHEMBL2945872

CC(C)=CC(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1

nearest known ligand 0.80

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
EGFR P00533 20/20 0.80
ERBB2 P04626 10/20 0.78
ERBB4 Q15303 3/20 0.77
FYN P06241 1/20 0.77
SRC P12931 1/20 0.77
BLK P51451 1/20 0.77
BMX P51813 1/20 0.77
JAK3 P52333 1/20 0.77
BTK Q06187 1/20 0.77
ABCG2 Q9UNQ0 1/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15782171 0.91 EGFR (0.75) EGFRERBB2ERBB4FYNSRC
SCHEMBL2986126 0.89 EGFR (1.00) EGFRERBB2ERBB4FYNSRC
SCHEMBL12012727 0.88 EGFR (1.00) EGFRERBB2ERBB4FYNSRC
SCHEMBL2988658 0.88 EGFR (1.00) EGFRERBB2ERBB4FYNSRC
SCHEMBL2988661 0.88 EGFR (1.00) EGFRERBB2ERBB4FYNSRC
SCHEMBL2680536 0.87 EGFR (1.00) EGFRERBB2ERBB4FYNSRC
SCHEMBL29359583 0.87 EGFR (1.00) EGFRERBB2ERBB4FYNSRC
SCHEMBL7213752 0.86 EGFR (0.89) EGFRERBB2ERBB4FYNSRC
SCHEMBL7212665 0.86 EGFR (0.89) EGFRERBB2ERBB4FYNSRC
SCHEMBL1417861 0.85 EGFR (1.00) EGFRERBB2ERBB4FYNSRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0980244-B1 USE OF QUINAZOLINE COMPOUNDS FOR THE TREATMENT OF POLYCYSTIC KIDNEY DISEASE WYETH CORP (US) 2003-06-04 EP claimed
US-6323209-B1 QUINAZOLINE COMPOUNDS IN THE TREATMENT AND INHIBITION OF COLONIC POLYPS. AMERICAN CYANAMID COMPANY 2001-11-27 US claimed
EP-1039910-A1 USE OF QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS FOR TREATING COLONIC POLYPS American Cyanamid Company (US) 2000-10-04 EP claimed
EP-0980244-A1 USE OF QUINAZOLINE COMPOUNDS FOR THE TREATMENT OF POLYCYSTIC KIDNEY DISEASE American Cyanamid Company (US) 2000-02-23 EP claimed
US-5929080-A ADMINISTERING PHENYLAMINOQUINAZOLINE DERIVATIVE AMERICAN CYANAMID COMPANY (US) 1999-07-27 US claimed
WO-1999024037-A1 USE OF QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS FOR TREATING COLONIC POLYPS AMERICAN CYANAMID COMPANY (US) 1999-05-20 WO claimed
WO-1998050038-A1 USE OF QUINAZOLINE COMPOUNDS FOR THE TREATMENT OF POLYCYSTIC KIDNEY DISEASE AMERICAN CYANAMID COMPANY (US) 1998-11-12 WO claimed
US-5760041-A 4-aminoquinazoline EGFR Inhibitors AMERICAN CYANAMID COMPANY (US) 1998-06-02 US claimed
EP-0787722-A1 Substituted quinazoline derivatives American Cyanamid Company (US) 1997-08-06 EP claimed
US-8765946-B2 Methods of preparing and using quinazoline and quinoline derivatives TIANJIN HEMAY ONCOLOGY PHARMACEUTICAL CO., LTD. (CN) 2014-07-01 US disclosed
US-8765946-B2 Methods of preparing and using quinazoline and quinoline derivatives TIANJIN HEMAY ONCOLOGY PHARMACEUTICAL CO., LTD. (CN) 2014-07-01 US disclosed
US-8765946-B2 Methods of preparing and using quinazoline and quinoline derivatives TIANJIN HEMAY ONCOLOGY PHARMACEUTICAL CO., LTD. (CN) 2014-07-01 US disclosed
EP-2045245-B1 INREVERSIBLE PROTEIN TYROSINE KINASES INHIBITORS AND THE PREPARATION METHODS AND USES THEREOF TIAN JIN HEMAY BIO TECH CO LTD (CN) 2013-10-23 EP disclosed
EP-2045245-B1 INREVERSIBLE PROTEIN TYROSINE KINASES INHIBITORS AND THE PREPARATION METHODS AND USES THEREOF TIAN JIN HEMAY BIO TECH CO LTD (CN) 2013-10-23 EP disclosed
EP-0980244-A1 USE OF QUINAZOLINE COMPOUNDS FOR THE TREATMENT OF POLYCYSTIC KIDNEY DISEASE American Cyanamid Company (US) 2000-02-23 EP disclosed
US-5929080-A ADMINISTERING PHENYLAMINOQUINAZOLINE DERIVATIVE AMERICAN CYANAMID COMPANY (US) 1999-07-27 US disclosed
WO-1999024037-A1 USE OF QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS FOR TREATING COLONIC POLYPS AMERICAN CYANAMID COMPANY (US) 1999-05-20 WO disclosed
WO-1998050038-A1 USE OF QUINAZOLINE COMPOUNDS FOR THE TREATMENT OF POLYCYSTIC KIDNEY DISEASE AMERICAN CYANAMID COMPANY (US) 1998-11-12 WO disclosed
US-5760041-A 4-aminoquinazoline EGFR Inhibitors AMERICAN CYANAMID COMPANY (US) 1998-06-02 US disclosed
EP-0787722-A1 Substituted quinazoline derivatives American Cyanamid Company (US) 1997-08-06 EP disclosed