Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 4/20 | 0.59 |
| ▸ | ABL1 | P00519 | 11/20 | 0.59 |
| ▸ | PDGFRA | P16234 | 7/20 | 0.59 |
| ▸ | BCR | P11274 | 6/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.59 |
| ▸ | EGFR | P00533 | 1/20 | 0.59 |
| ▸ | PRKCA | P17252 | 1/20 | 0.59 |
| ▸ | KDR | P35968 | 3/20 | 0.57 |
| ▸ | KIT | P10721 | 3/20 | 0.57 |
| ▸ | TEK | Q02763 | 1/20 | 0.57 |
| ▸ | CSF1R | P07333 | 1/20 | 0.56 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2940451 | 0.91 | ABL1 (0.59) | BRAFABL1PDGFRABCRPDGFRB | |
| SCHEMBL2942477 | 0.90 | BRAF (0.61) | BRAFABL1PDGFRABCRPDGFRB | |
| SCHEMBL2945905 | 0.89 | BTK (0.58) | BRAFABL1PDGFRABCRPDGFRB | |
| SCHEMBL2941616 | 0.87 | KIT (0.61) | BRAFABL1PDGFRABCRPDGFRB | |
| SCHEMBL2941258 | 0.87 | ABL1 (0.55) | BRAFABL1PDGFRABCRPDGFRB | |
| SCHEMBL1408815 | 0.87 | ABL1 (0.77) | BRAFABL1PDGFRABCRPDGFRB | |
| SCHEMBL30899721 | 0.87 | ABL1 (0.67) | BRAFABL1PDGFRABCRPDGFRB | |
| SCHEMBL2941693 | 0.87 | ABL1 (0.67) | BRAFABL1PDGFRABCRPDGFRB | |
| SCHEMBL2940107 | 0.87 | KDR (0.57) | BRAFABL1PDGFRABCRPDGFRB | |
| SCHEMBL2945359 | 0.86 | ABL1 (0.70) | BRAFABL1PDGFRABCRPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1635835-B1 | 2-AMINOPYRIMIDINE DERIVATIVES AS RAF KINASE INHIBITORS | NOVARTIS AG (CH) | 2010-01-06 | — | — | EP | claimed |
| EP-1635835-B1 | 2-AMINOPYRIMIDINE DERIVATIVES AS RAF KINASE INHIBITORS | NOVARTIS AG (CH) | 2010-01-06 | — | — | EP | disclosed |
| EP-1635835-B1 | 2-AMINOPYRIMIDINE DERIVATIVES AS RAF KINASE INHIBITORS | NOVARTIS AG (CH) | 2010-01-06 | — | — | EP | disclosed |