Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 18/20 | 0.65 |
| ▸ | KIT | P10721 | 10/20 | 0.65 |
| ▸ | KDR | P35968 | 9/20 | 0.65 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.65 |
| ▸ | LCK | P06239 | 6/20 | 0.64 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.60 |
| ▸ | LYN | P07948 | 1/20 | 0.54 |
| ▸ | CSF1R | P07333 | 1/20 | 0.50 |
| ▸ | SGK1 | O00141 | 1/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2954459 | 0.84 | MAPK14 (0.69) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2952789 | 0.84 | MAPK14 (0.65) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2944485 | 0.84 | MAPK14 (0.65) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2954195 | 0.84 | MAPK14 (0.69) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2951745 | 0.84 | MAPK14 (0.65) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2952465 | 0.83 | MAPK14 (0.64) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2951561 | 0.83 | MAPK14 (0.64) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2955157 | 0.82 | MAPK14 (0.60) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2953010 | 0.82 | MAPK14 (0.60) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL2954613 | 0.81 | MAPK14 (0.79) | MAPK14KITKDRMAPK9LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7759337-B2 | Phthalazine compounds and methods of use | AMGEN INC. (US) | 2010-07-20 | — | — | US | claimed |