Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGA5 | P08648 | 1/20 | 0.43 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.43 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MTOR | P42345 | 2/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.38 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.38 |
| ▸ | TEK | Q02763 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21821308 | 1.00 | ITGA5 (0.43) | ITGA5ITGB6ITGB8SMN1; SMN2NPC1 | |
| SCHEMBL19284026 | 0.91 | ITGA5 (0.48) | ITGA5ITGB6ITGB8SMN1; SMN2NPC1 | |
| SCHEMBL19283618 | 0.91 | ITGA5 (0.44) | ITGA5ITGB6ITGB8SMN1; SMN2NPC1 | |
| SCHEMBL21821320 | 0.90 | ITGA5 (0.42) | ITGA5ITGB6ITGB8SMN1; SMN2NPC1 | |
| SCHEMBL19283637 | 0.89 | ITGA5 (0.47) | ITGA5ITGB6ITGB8SMN1; SMN2NPC1 | |
| SCHEMBL19283701 | 0.89 | ITGA5 (0.43) | ITGA5ITGB6ITGB8SMN1; SMN2NPC1 | |
| SCHEMBL20743128 | 0.89 | ITGA5 (0.45) | ITGA5ITGB6ITGB8SMN1; SMN2NPC1 | |
| SCHEMBL30645012 | 0.89 | ITGA5 (0.45) | ITGA5ITGB6ITGB8SMN1; SMN2NPC1 | |
| SCHEMBL19283650 | 0.88 | ITGA5 (0.44) | ITGA5ITGB6ITGB8SMN1; SMN2NPC1 | |
| SCHEMBL19283502 | 0.87 | ITGA5 (0.45) | ITGA5ITGB6ITGB8SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11274092-B2 | Potassium channel inhibitors | ACESION PHARMA APS (DK) | 2022-03-15 | — | — | US | claimed |
| US-11274092-B2 | Potassium channel inhibitors | ACESION PHARMA APS (DK) | 2022-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11274092-B2 | Potassium channel inhibitors | KCNJ2, KCNJ11, KCNJ1 | ITGA5 2293/4885ITGB6 2913/4885ITGB8 3978/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.