Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNT1 | Q5JUK3 | 11/20 | 0.51 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.51 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.51 |
| ▸ | KCNMB1 | Q16558 | 1/20 | 0.51 |
| ▸ | KCNT2 | Q6UVM3 | 1/20 | 0.51 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22637731 | 1.00 | KCNT1 (0.51) | KCNT1KCNQ1KCNH2CACNA1CSCN5A | |
| SCHEMBL22637730 | 1.00 | KCNT1 (0.51) | KCNT1KCNQ1KCNH2CACNA1CSCN5A | |
| SCHEMBL28710638 | 0.86 | KCNT1 (0.56) | KCNT1KCNQ1KCNH2CACNA1CSCN5A | |
| SCHEMBL22649328 | 0.86 | KCNT1 (0.56) | KCNT1KCNQ1KCNH2CACNA1CSCN5A | |
| Hydrochloric Acid SCHEMBL28705236 | 0.85 | KCNT1 (0.55) | KCNT1KCNQ1KCNH2CACNA1CSCN5A | |
| Hydrochloric Acid SCHEMBL28705235 | 0.85 | KCNT1 (0.55) | KCNT1KCNQ1KCNH2CACNA1CSCN5A | |
| SCHEMBL15479767 | 0.83 | KCNT1 (0.58) | KCNT1KCNQ1KCNH2CACNA1CSCN5A | |
| SCHEMBL22637953 | 0.82 | S1PR1 (0.47) | KCNT1S1PR1 | |
| SCHEMBL22637952 | 0.82 | S1PR1 (0.47) | KCNT1S1PR1 | |
| SCHEMBL29463528 | 0.82 | S1PR1 (0.47) | KCNT1S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115443129-A | KCNT1 inhibitors and methods of use | 普拉西斯精密医药公司 | 2022-12-06 | — | — | CN | disclosed |
| CN-114269340-A | KCNT1 inhibitors and methods of use | 普拉克西斯精密药物股份有限公司 | 2022-04-01 | — | — | CN | disclosed |
| EP-3962481-A1 | KCNT1 INHIBITORS AND METHODS OF USE | Praxis Precision Medicines, Inc. (US) | 2022-03-09 | — | — | EP | disclosed |