Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | AHR | P35869 | 3/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.42 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
| ▸ | HNF4A | P41235 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6316182 | 1.00 | HSD17B10 (0.46) | HSD17B10ALDH1A1TDP1TSHRCYP2A6 | |
| SCHEMBL16212768 | 0.85 | CYP2A6 (0.42) | ALDH1A1TDP1CYP2A6L3MBTL1CYP1A2 | |
| SCHEMBL20530598 | 0.85 | CYP1A2 (0.48) | HSD17B10ALDH1A1TDP1TSHRCYP2A6 | |
| SCHEMBL30091394 | 0.81 | TDP1 (0.55) | HSD17B10ALDH1A1TDP1TSHRCYP2A6 | |
| SCHEMBL415466 | 0.81 | TDP1 (0.55) | HSD17B10ALDH1A1TDP1TSHRCYP2A6 | |
| SCHEMBL20480431 | 0.81 | MCL1 (0.42) | HSD17B10ALDH1A1TDP1TSHRL3MBTL1 | |
| SCHEMBL1148375 | 0.80 | MCL1 (0.35) | HSD17B10ALDH1A1TDP1TSHRL3MBTL1 | |
| SCHEMBL14406000 | 0.80 | MAPT (0.38) | TDP1L3MBTL1CYP1A2ABCG2HNF4A | |
| SCHEMBL14382011 | 0.78 | KDM4E (0.34) | HSD17B10ALDH1A1TDP1TSHRCYP1A2 | |
| SCHEMBL14406007 | 0.77 | KMT2A (0.40) | CYP1A2HPGDCYP3A4MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114085185-A | Process for preparing bedaquiline and pharmaceutically acceptable salts thereof | 东亚ST 株式会社 | 2022-02-25 | — | — | CN | claimed |
| US-12319947-B2 | Method for preparing (S)-nicotine by reduction | PORTON PHARMA SOLUTIONS LTD. (CN) | 2025-06-03 | — | — | US | disclosed |
| CN-114085185-B | Method for preparing bedaquiline and pharmaceutically acceptable salts thereof | 东亚ST 株式会社 | 2024-09-24 | — | — | CN | disclosed |
| US-20240124908-A1 | METHOD FOR PREPARING (S)-NICOTINE BY REDUCTION | PORTON PHARMA SOLUTIONS LTD. (CN) | 2024-04-18 | — | — | US | disclosed |
| CN-114085185-A | Process for preparing bedaquiline and pharmaceutically acceptable salts thereof | 东亚ST 株式会社 | 2022-02-25 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12319947-B2 | Method for preparing (S)-nicotine by reduction | NAPRT, CHRNA5, CHRNA7 | HSD17B10 1066/4885ALDH1A1 619/4885TDP1 3849/4885 |
| US-20240124908-A1 | METHOD FOR PREPARING (S)-NICOTINE BY REDUCTION | NAPRT, CHRNA5, CHRNA7 | HSD17B10 1066/4885ALDH1A1 619/4885TDP1 3849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.