Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 9/20 | 0.49 |
| ▸ | AKT1 | P31749 | 6/20 | 0.49 |
| ▸ | MTOR | P42345 | 5/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.49 |
| ▸ | AKT2 | P31751 | 1/20 | 0.45 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.45 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 7/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2924265 | 0.88 | PIK3CA (0.52) | PIK3CAAKT1MTORPIK3CBPIK3CD | |
| SCHEMBL2926918 | 0.85 | PIK3CA (0.53) | PIK3CAAKT1MTORPIK3CBPIK3CD | |
| SCHEMBL2920507 | 0.84 | PIK3CA (0.51) | PIK3CAAKT1MTORPIK3CBPIK3CD | |
| SCHEMBL2923640 | 0.80 | PIK3CA (0.50) | PIK3CAAKT1MTORPIK3CBPIK3CD | |
| SCHEMBL2917989 | 0.77 | PIK3CA (0.65) | PIK3CAAKT1MTORPIK3CBPIK3CD | |
| SCHEMBL2923282 | 0.75 | PIK3CA (0.49) | PIK3CAAKT1MTORPIK3CBPIK3CD | |
| SCHEMBL2927119 | 0.74 | AKT1 (0.48) | PIK3CAAKT1MTORPIK3CBPIK3CD | |
| SCHEMBL2930380 | 0.74 | PIK3CA (0.46) | PIK3CAAKT1MTORPIK3CBPIK3CD | |
| SCHEMBL2918526 | 0.74 | PIK3CA (0.76) | PIK3CAAKT1MTORPIK3CBPIK3CD | |
| SCHEMBL2923077 | 0.73 | PIK3CA (0.47) | PIK3CAAKT1MTORPIK3CBPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231661-A1 | INHIBITORS OF PI3 KINASE | Amgen, Inc. (US) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009085230-A1 | INHIBITORS OF PI3 KINASE | AMGEN INC. (US) | 2009-07-09 | — | — | WO | disclosed |