Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 5/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.58 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.58 |
| ▸ | CHRNG | P07510 | 2/20 | 0.58 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.58 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.58 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.58 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.58 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.58 |
| ▸ | CHRND | Q07001 | 2/20 | 0.58 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | HRH1 | P35367 | 1/20 | 0.58 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25499709 | 1.00 | SLC6A2 (0.58) | SLC6A2SLC6A3CHRNA1CHRNGCHRNB1 | |
| SCHEMBL770030 | 1.00 | SLC6A2 (0.58) | SLC6A2SLC6A3CHRNA1CHRNGCHRNB1 | |
| SCHEMBL8203173 | 0.85 | SLC6A2 (0.58) | SLC6A2SLC6A3CHRNA1CHRNGCHRNB1 | |
| SCHEMBL769582 | 0.84 | SLC6A2 (0.56) | SLC6A2SLC6A3CHRNA1CHRNGCHRNB1 | |
| Hydrochloric Acid SCHEMBL5858783 | 0.83 | SLC6A2 (0.57) | SLC6A2SLC6A3CHRNA1CHRNGCHRNB1 | |
| SCHEMBL13973202 | 0.82 | SLC6A2 (0.56) | SLC6A2SLC6A3CHRNA1CHRNGCHRNB1 | |
| SCHEMBL22398923 | 0.79 | SLC6A2 (0.52) | SLC6A2SLC6A3CHRNA1CHRNGCHRNB1 | |
| SCHEMBL23571741 | 0.78 | SLC6A2 (0.65) | SLC6A2SLC6A3CHRNA1CHRNGCHRNB1 | |
| SCHEMBL16698541 | 0.77 | SLC6A2 (0.50) | SLC6A2SLC6A3CHRNA1CHRNGCHRNB1 | |
| SCHEMBL634022 | 0.77 | HRH1 (0.66) | SLC6A2SLC6A3CHRNA1CHRNGCHRNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115697314-A | Use of bupropion and dextromethorphan combinations for treating neurological disorders | 安泰赛普生物风投二代有限责任公司 | 2023-02-03 | — | — | CN | disclosed |
| CN-114712357-A | Combination of dextromethorphan and bupropion for the treatment of depression | 安泰赛普生物风投二代有限责任公司 | 2022-07-08 | — | — | CN | disclosed |
| CN-114712356-A | Combination of dextromethorphan and bupropion for the treatment of depression | 安泰赛普生物风投二代有限责任公司 | 2022-07-08 | — | — | CN | disclosed |
| CN-114712358-A | Combination of dextromethorphan and bupropion for the treatment of depression | 安泰赛普生物风投二代有限责任公司 | 2022-07-08 | — | — | CN | disclosed |
| CN-112437659-B | Combination of dextromethorphan and bupropion for the treatment of depression | 安泰赛普生物风投二代有限责任公司 | 2022-04-12 | — | — | CN | disclosed |