Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 20/20 | 1.00 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22772890 | 1.00 | GRIN2B (1.00) | GRIN2BGRIN1 | |
| SCHEMBL29465733 | 0.90 | GRIN2B (1.00) | GRIN2BGRIN1 | |
| SCHEMBL22772827 | 0.90 | GRIN2B (1.00) | GRIN2BGRIN1 | |
| SCHEMBL22772853 | 0.85 | GRIN2B (1.00) | GRIN2B | |
| SCHEMBL29465723 | 0.85 | GRIN2B (1.00) | GRIN2B | |
| SCHEMBL22772882 | 0.84 | GRIN2B (1.00) | GRIN2B | |
| SCHEMBL29465726 | 0.84 | GRIN2B (1.00) | GRIN2B | |
| SCHEMBL22775884 | 0.84 | GRIN2B (0.72) | GRIN2BGRIN1 | |
| SCHEMBL29550480 | 0.84 | GRIN2B (0.72) | GRIN2BGRIN1 | |
| SCHEMBL22772864 | 0.81 | GRIN2B (1.00) | GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3983413-A1 | SUBSTITUTED PYRAZOLO-PYRAZINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | Janssen Pharmaceutica NV (BE) | 2022-04-20 | — | — | EP | claimed |
| EP-3983413-A1 | SUBSTITUTED PYRAZOLO-PYRAZINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | Janssen Pharmaceutica NV (BE) | 2022-04-20 | — | — | EP | disclosed |