Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 5/20 | 0.60 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.58 |
| ▸ | AURKA | O14965 | 6/20 | 0.57 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.56 |
| ▸ | IKBKB | O14920 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.56 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.56 |
| ▸ | PRKCG | P05129 | 1/20 | 0.56 |
| ▸ | CDK1 | P06493 | 1/20 | 0.56 |
| ▸ | LYN | P07948 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | KIT | P10721 | 1/20 | 0.56 |
| ▸ | PIM1 | P11309 | 1/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.56 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.56 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.56 |
| ▸ | CDK2 | P24941 | 1/20 | 0.56 |
| ▸ | MARK3 | P27448 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL670431 | 0.87 | KDM4E (0.62) | MAPK8MAPK10AURKAPRKCDCHEK1 | |
| SCHEMBL29484634 | 0.87 | AURKA (0.59) | MAPK8MAPK10AURKAPRKCDCHEK1 | |
| SCHEMBL29938984 | 0.84 | MAPT (0.58) | MAPK8MAPK10AURKANPC1MAPT | |
| SCHEMBL5598434 | 0.84 | JAK2 (0.57) | MAPK8MAPK10AURKAPRKCDCHEK1 | |
| SCHEMBL25882561 | 0.82 | GSK3A (0.50) | MAPK8AURKAPRKCDCHEK1IKBKB | |
| SCHEMBL29466335 | 0.82 | GSK3A (0.50) | MAPK8AURKAPRKCDCHEK1IKBKB | |
| SCHEMBL29466300 | 0.81 | AURKA (0.45) | MAPK8MAPK10AURKANPC1CDK1 | |
| SCHEMBL670174 | 0.81 | AURKA (0.53) | MAPK8AURKAPRKCDCHEK1IKBKB | |
| SCHEMBL25883208 | 0.81 | GSK3A (0.58) | MAPK8AURKAPRKCDCHEK1IKBKB | |
| SCHEMBL29939485 | 0.81 | GSK3A (0.55) | MAPK8MAPK10AURKAIKBKBKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110545817-B | GSK-3 inhibitors | 百时美施贵宝公司 | 2022-11-15 | — | — | CN | disclosed |
| CN-114195780-A | Carbonyl heterocyclic compound and application thereof | 上海医药集团股份有限公司 | 2022-03-18 | — | — | CN | disclosed |
| CN-114195806-A | Carbonyl heterocyclic compound and application thereof | 上海医药集团股份有限公司 | 2022-03-18 | — | — | CN | disclosed |