Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | TYK2 | P29597 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | DUT | P33316 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22638007 | 1.00 | JAK2 (0.40) | JAK2JAK1TYK2JAK3DUT | |
| SCHEMBL22638029 | 0.83 | JAK2 (0.48) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL22638003 | 0.78 | JAK2 (0.45) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL29467010 | 0.78 | JAK2 (0.45) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL22648842 | 0.78 | JAK2 (0.45) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL22638005 | 0.75 | JAK2 (0.41) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL23168749 | 0.72 | JAK2 (0.39) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL22648913 | 0.72 | JAK2 (0.39) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL22686552 | 0.72 | JAK2 (0.39) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL29467008 | 0.72 | JAK2 (0.39) | JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3966209-A1 | JAK INHIBITORS | Vimalan Biosciences, Inc. (US) | 2022-03-16 | — | — | EP | disclosed |