Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 13/20 | 0.54 |
| ▸ | JAK2 | O60674 | 12/20 | 0.52 |
| ▸ | TYK2 | P29597 | 3/20 | 0.52 |
| ▸ | JAK3 | P52333 | 2/20 | 0.52 |
| ▸ | IKBKB | O14920 | 1/20 | 0.52 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | SYK | P43405 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29469304 | 0.85 | JAK1 (0.58) | JAK1JAK2TYK2JAK3IKBKB | |
| SCHEMBL29469323 | 0.84 | TYK2 (0.58) | JAK1JAK2TYK2JAK3IKBKB | |
| SCHEMBL29469373 | 0.84 | TYK2 (0.58) | JAK1JAK2TYK2JAK3IKBKB | |
| SCHEMBL13031373 | 0.82 | JAK1 (0.71) | JAK1JAK2TYK2JAK3IKBKB | |
| SCHEMBL13031432 | 0.81 | JAK2 (0.74) | JAK1JAK2TYK2JAK3IKBKB | |
| SCHEMBL29469325 | 0.80 | JAK1 (0.54) | JAK1JAK2TYK2JAK3IKBKB | |
| SCHEMBL13031327 | 0.72 | JAK3 (0.71) | JAK1JAK2TYK2JAK3IKBKB | |
| SCHEMBL13031358 | 0.72 | JAK1 (0.78) | JAK1JAK2TYK2JAK3IKBKB | |
| SCHEMBL11916701 | 0.71 | JAK1 (1.00) | JAK1JAK2TYK2JAK3IKBKB | |
| SCHEMBL13031280 | 0.71 | JAK1 (0.77) | JAK1JAK2TYK2JAK3IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114075189-A | Five-membered heterocyclic acene ring compound and preparation method and medical application thereof | 南京柯菲平盛辉制药有限公司 | 2022-02-22 | — | — | CN | disclosed |